Utilising path-vertex data to improve Monte Carlo global illumination.

Efficient techniques for photo-realistic rendering are in high demand across a wide array of industries. Notable applications include visual effects for film, entertainment and virtual reality. Less direct applications such as visualisation for architecture, lighting design and product development also rely on the synthesis of realistic and physically based illumination. Such applications assert ever increasing demands on light transport algorithms, requiring the computation of photo-realistic effects while handling complex geometry, light scattering models and illumination. Techniques based on Monte Carlo integration handle such scenarios elegantly and robustly, but despite seeing decades of focused research and wide commercial support, these methods and their derivatives still exhibit undesirable side effects that are yet to be resolved. In this thesis, Monte Carlo path tracing techniques are improved upon by utilizing path vertex data and intermediate radiance contributions readily available during rendering. This permits the development of novel progressive algorithms that render low noise global illumination while striving to maintain the desirable accuracy and convergence properties of unbiased methods. The thesis starts by presenting a discussion into optical phenomenon, physically based rendering and achieving photo realistic image synthesis. This is followed by in-depth discussion of the published theoretical and practical research in this field, with a focus on stochastic methods and modem rendering methodologies. This provides insight into the issues surrounding Monte Carlo integration both in the general and rendering specific contexts, along with an appreciation for the complexities of solving global light transport. Alternative methods that aim to address these issues are discussed, providing an insight into modem rendering paradigms and their characteristics. Thus, an understanding of the key aspects is obtained, that is necessary to build up and discuss the novel research and contributions to the field developed throughout this thesis. First, a path space filtering strategy is proposed that allows the path-based space of light transport to be classified into distinct subsets. This permits the novel combination of robust path tracing and recent progressive photon mapping algorithms to handle each subset based on the characteristics of the light transport in that space. This produces a hybrid progressive rendering technique that utilises the strengths of existing state of the art Monte Carlo and photon mapping methods to provide efficient and consistent rendering of complex scenes with vanishing bias. The second original contribution is a probabilistic image-based filtering and sample clustering framework that provides high quality previews of global illumination whilst remaining aware of high frequency detail and features in geometry, materials and the incident illumination. As will be seen, the challenges of edge-aware noise reduction are numerous and long standing, particularly when identifying high frequency features in noisy illumination signals. Discontinuities such as hard shadows and glossy reflections are commonly overlooked by progressive filtering techniques, however by dividing path space into multiple layers, once again based on utilising path vertex data, the overlapping illumination of varying intensities, colours and frequencies is more effectively handled. Thus noise is removed from each layer independent of features present in the remaining path space, effectively preserving such features

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.

Importance Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness and safety of these noninvasive respiratory strategies. Objective To determine whether either CPAP or HFNO, compared with conventional oxygen therapy, improves clinical outcomes in hospitalized patients with COVID-19-related acute hypoxemic respiratory failure. Design, Setting, and Participants A parallel group, adaptive, randomized clinical trial of 1273 hospitalized adults with COVID-19-related acute hypoxemic respiratory failure. The trial was conducted between April 6, 2020, and May 3, 2021, across 48 acute care hospitals in the UK and Jersey. Final follow-up occurred on June 20, 2021. Interventions Adult patients were randomized to receive CPAP (n = 380), HFNO (n = 418), or conventional oxygen therapy (n = 475). Main Outcomes and Measures The primary outcome was a composite of tracheal intubation or mortality within 30 days. Results The trial was stopped prematurely due to declining COVID-19 case numbers in the UK and the end of the funded recruitment period. Of the 1273 randomized patients (mean age, 57.4 [95% CI, 56.7 to 58.1] years; 66% male; 65% White race), primary outcome data were available for 1260. Crossover between interventions occurred in 17.1% of participants (15.3% in the CPAP group, 11.5% in the HFNO group, and 23.6% in the conventional oxygen therapy group). The requirement for tracheal intubation or mortality within 30 days was significantly lower with CPAP (36.3%; 137 of 377 participants) vs conventional oxygen therapy (44.4%; 158 of 356 participants) (absolute difference, -8% [95% CI, -15% to -1%], P = .03), but was not significantly different with HFNO (44.3%; 184 of 415 participants) vs conventional oxygen therapy (45.1%; 166 of 368 participants) (absolute difference, -1% [95% CI, -8% to 6%], P = .83). Adverse events occurred in 34.2% (130/380) of participants in the CPAP group, 20.6% (86/418) in the HFNO group, and 13.9% (66/475) in the conventional oxygen therapy group. Conclusions and Relevance Among patients with acute hypoxemic respiratory failure due to COVID-19, an initial strategy of CPAP significantly reduced the risk of tracheal intubation or mortality compared with conventional oxygen therapy, but there was no significant difference between an initial strategy of HFNO compared with conventional oxygen therapy. The study may have been underpowered for the comparison of HFNO vs conventional oxygen therapy, and early study termination and crossover among the groups should be considered when interpreting the findings. Trial Registration isrctn.org Identifier: ISRCTN16912075